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Side Effects You May Have While Taking SPRYCEL® (dasatinib)
The following information describes the serious side effects Side effect(s): an undesired, usually negative, effect of a drug of SPRYCEL that you should be aware of. These are not all of the possible side effects of SPRYCEL. Ask your doctor what to do if you experience any side effects.
Low Blood Cell Counts
Low blood cell counts are common with SPRYCEL and can be severe, including low red blood cell counts (anemia), low white blood cell counts (neutropenia), and low platelet counts (thrombocytopenia). Your healthcare provider will do blood tests to check your blood cell counts regularly during your treatment with SPRYCEL. Call your healthcare provider right away if you have a fever or any signs of an infection during treatment with SPRYCEL.
SPRYCEL may cause severe bleeding that can lead to death. Call your healthcare provider right away if you have:
- Unusual bleeding or bruising of your skin
- Bright red or dark tar-like stools
- Decreased alertness, headache, or change in speech
Your body may hold too much fluid (fluid retention)
Fluid retention is common with SPRYCEL and can sometimes be severe. In severe cases, fluid may build up in the lining of your lungs, the sac around your heart, or your stomach cavity. Call your healthcare provider right away if you get any of these symptoms during treatment with SPRYCEL:
- Swelling all over your body
- Weight gain
- Shortness of breath and cough, especially if this happens with low levels of physical activity or at rest
- Chest pain when taking a deep breath
Your healthcare provider may be able to manage the fluid retention without having to change your medication.
SPRYCEL may cause an abnormal heart rate, heart problems, or a heart attack that can lead to death. Your healthcare provider will monitor the potassium and magnesium levels in your blood, and your heart function.
Pulmonary Arterial Hypertension (PAH)
SPRYCEL may cause high blood pressure in the vessels of your lungs. PAH may happen at any time during your treatment with SPRYCEL. Your healthcare provider should check your heart and lungs before and during your treatment with SPRYCEL. Call your healthcare provider right away if you have shortness of breath, tiredness, or swelling all over your body (fluid retention).
Severe Skin Reactions
SPRYCEL may cause skin reactions that can sometimes be severe. Get medical help right away if you get a skin reaction with fever, sore mouth or throat, or blistering or peeling of your skin or in the mouth.
Tumor Lysis Syndrome (TLS)
TLS is caused by a fast breakdown of cancer cells. TLS can cause kidney failure and an abnormal heart beat. Kidney failure may require the need for dialysis treatment. Your healthcare provider may do blood tests to check you for TLS.
Side effects of SPRYCEL which are considered common include: diarrhea, headache, tiredness, nausea, shortness of breath, skin rash, muscle pain, and fever. This is not a complete list of all side effects with SPRYCEL. Tell your healthcare provider if you have any side effects while taking SPRYCEL.
What Can I Do About Possible Side Effects?
Ask your healthcare provider about which side effects are most likely to occur, what symptoms you should watch for, how long the side effects might last, and how serious they might be.
If you experience any side effects, even if they appear minor to you, report them to your healthcare provider.
Your healthcare team will work with you to help reduce the discomfort of some of the side effects you might experience. Here are some tips you might find helpful:
Slowly sip clear, cold liquids such as ginger ale, apple juice, broth, and iced tea. Ice chips or chips of frozen juice can be taken slowly as well. Try eating bland foods and avoiding fatty, fried, spicy, or sweet foods.
Avoid greasy food, bran, raw fruits and vegetables, caffeine, pastries, hot or spicy foods, acidic drinks, milk products, candies, rich desserts, jellies, preserves, nuts, alcohol, and tobacco.
Schedule your activities throughout the day; ask friends and family members to help with cooking, yard work, housework, and errands; and do not force yourself to do more than you can manage.