Clinical Trials in Children
Have there been any clinical trials with SPRYCEL® (dasatinib) in children?
SPRYCEL has been studied in children with Ph+ CML in chronic phase. The information shown here is from a combined analysis of two clinical trials that included 51 newly diagnosed and 46 previously treated children, for a total of 97.
What were the main goals of the trials?
The main goals were to find out the effects of SPRYCEL on:
Complete Cytogenetic Response (CCyR)
Occurs in the bone marrow, not just the blood. A Complete Cytogenetic Response means that there were no signs of bad cells.
Major Cytogenetic Response (MCyR)
Measures a decrease in the amount of bad cells in the bone marrow.
Major Molecular Response (MMR)
Means that the amount of BCR-ABL protein is very low.
What were the results with SPRYCEL?
Important Side Effect Information
Tell your healthcare provider about all the medicines you take, including prescription and over-the counter medicines, vitamins, antacids, and herbal supplements, including St. John’s Wort. Talk to your doctor about how these medicines or other products may interact with SPRYCEL.
If you take an antacid medicine, take it 2 hours before or 2 hours after your dose of SPRYCEL.
You should not drink grapefruit juice during treatment with SPRYCEL.